Bipolar and Related Disorders
Bipolar I Disorder
ICD-10-CM: F31.9
1. Criteria
DSM Criteria
Criterion A
- A manic episode is a distinct period of abnormally and persistently elevated, expansive, or irritable mood together with abnormally and persistently increased activity or energy.
- The episode lasts at least 1 week and is present most of the day, nearly every day, unless hospitalization is required sooner.
DSM Criteria
Criterion B
- During the period of mood disturbance and increased energy or activity, 3 or more of the following symptoms are present to a significant degree, or 4 if the mood is only irritable:
- Inflated self-esteem or grandiosity.
- Decreased need for sleep.
- More talkative than usual or pressure to keep talking.
- Flight of ideas or racing thoughts.
- Distractibility.
- Increase in goal-directed activity or psychomotor agitation.
- Excessive involvement in risky or high-consequence activities.
DSM Criteria
Criterion C
- The episode is severe enough to cause marked impairment in social or occupational functioning, require hospitalization to prevent harm, or include psychotic features.
DSM Criteria
Criterion D
- The episode is not attributable to substances or another medical condition.
- If mania emerges during antidepressant treatment but persists beyond the physiologic effect of treatment, it counts as a manic episode.
2. Context
- Bipolar I disorder is defined by mania. Many patients spend more time depressed than manic, but a single true manic episode changes the diagnostic frame and has major implications for risk, treatment, and long-term planning.
- Defining feature: A full manic episode is enough for the diagnosis, even if the person has never had a major depressive episode.
- High-risk points: The highest-stakes questions are usually about psychosis, impulsivity, suicidality, spending, sexual risk, agitation, and how fast functioning is falling apart.
- Treatment lens: Treatment decisions usually make the most sense when you anchor them to polarity: acute mania, bipolar depression, or maintenance after stabilization.
- Clinical focus: Standard clinician-rated tool for manic symptom severity.
3. Validated scales
YMRS
Standard clinician-rated tool for manic symptom severity.
CGI-BP
Quick global severity and improvement tracking across polarity states.
MADRS
Often paired with bipolar depression monitoring.
Altman Self-Rating Mania Scale
Brief self-report check for manic symptoms between visits.
4. FDA approved treatments
Acute mania or mixed episodes
FDA-indicated options commonly used for manic or mixed states; some are also used in maintenance after stabilization.
Bipolar depression
FDA-indicated medications specifically tied to bipolar depressive episodes in bipolar I disorder or bipolar depression labeling.
Maintenance treatment
Maintenance choices are used to reduce recurrence risk after acute stabilization and should be individualized by polarity pattern.
Common off-label medications
Interventional psychiatry modalities
- ECT is used in severe mania, psychotic mood episodes, and refractory bipolar depression.
- Ketamine is being studied and used selectively for bipolar depression in specialty settings.
- TMS is under study and used off-label in some bipolar depression programs.
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5. Top management articles
- The CANMAT and ISBD guidelines for the management of patients with bipolar disorder Bipolar Disorders, 2018 update lineage
- Treatment of bipolar disorder The Lancet, 2013
- Maintenance treatment in bipolar disorder: what do guidelines recommend? Review literature