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Treatments and Medications

Bipolar I Disorder Treatments and Medications

This page summarizes the main treatment lanes attached to Bipolar I Disorder and links back to the full diagnosis profile.

Main diagnosis page

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Acute mania or mixed episodes

  • FDA-indicated options commonly used for manic or mixed states; some are also used in maintenance after stabilization.
  • Medications: Lithium, Divalproex, Carbamazepine, Olanzapine, Quetiapine, Risperidone, Aripiprazole, Ziprasidone, Asenapine, Cariprazine

Bipolar depression

  • FDA-indicated medications specifically tied to bipolar depressive episodes in bipolar I disorder or bipolar depression labeling.
  • Medications: Quetiapine, Lurasidone, Cariprazine, Lumateperone, Olanzapine/Fluoxetine

Maintenance treatment

  • Maintenance choices are used to reduce recurrence risk after acute stabilization and should be individualized by polarity pattern.
  • Medications: Lithium, Lamotrigine, Aripiprazole, Olanzapine, Quetiapine, Ziprasidone

Common off-label medications

  • Lamotrigine
  • Oxcarbazepine
  • Clozapine

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