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Return to the full Major Depressive Disorder pillar page.

Acute treatment of major depressive disorder

• Common FDA-indicated antidepressants for MDD; agent choice still depends on age, comorbidity, and adverse-effect profile.
• Medications: Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, Bupropion, Venlafaxine XR, Desvenlafaxine, Duloxetine, Levomilnacipran ER, Vilazodone, Vortioxetine, Mirtazapine, Trazodone

Adjunctive treatment for major depressive disorder

• These are FDA-indicated as add-on treatments rather than stand-alone first-line monotherapy for routine MDD care.
• Medications: Aripiprazole, Brexpiprazole, Quetiapine XR

Common off-label medications

• Lithium
• Lamotrigine
• Modafinil

Related Guides

• Major Depressive Disorder Symptoms and Signs
• Major Depressive Disorder DSM Criteria Guide
• Major Depressive Disorder Scales and Assessment Tools
• When to Seek Professional Help for Major Depressive Disorder