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Sleep-Wake Disorders

Narcolepsy

ICD-10-CM: G47.419

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1. Criteria

DSM Criteria

Criterion A

  • There are recurrent periods of irrepressible need to sleep, lapsing into sleep, or napping within the same day.
  • These episodes occur at least 3 times per week over the past 3 months.

DSM Criteria

Criterion B

  • At least one of the following is present: episodes of cataplexy, hypocretin deficiency, or REM sleep latency abnormalities on sleep testing consistent with narcolepsy.

2. Context

  • Narcolepsy is a central disorder of sleep-wake regulation marked by chronic daytime sleepiness and, in some patients, cataplexy, REM-related hallucinations, sleep paralysis, or fragmented nighttime sleep. In practice, the story often comes out as irresistible sleep episodes and a lifetime of feeling abnormally sleepy.
  • Core symptom: Excessive daytime sleepiness is the anchor symptom. The person is often sleepy even after what sounds like adequate nighttime sleep.
  • Cataplexy matters: When present, cataplexy strongly shifts the differential and points toward narcolepsy type 1.
  • Workup: Diagnosis usually depends on sleep medicine testing, especially polysomnography plus MSLT, and sometimes CSF hypocretin data.
  • Clinical focus: Common office-based measure of subjective daytime sleepiness.

3. Validated scales

Epworth Sleepiness Scale

Common office-based measure of subjective daytime sleepiness.

Multiple Sleep Latency Test

Core specialist diagnostic test in narcolepsy evaluation.

Maintenance of Wakefulness Test

Useful in follow-up when ability to stay awake is the key clinical question.

4. FDA approved treatments

FDA-approved medications for excessive daytime sleepiness in narcolepsy

Several wake-promoting agents and alerting medications carry narcolepsy labeling, though product-specific indications and age ranges differ.

FDA-approved medications for cataplexy or mixed narcolepsy symptoms

Oxybate products are important FDA-approved options when cataplexy or severe daytime sleepiness is part of the narcolepsy picture.

Interventional psychiatry modalities

  • Interventional psychiatry modalities are not standard treatments for narcolepsy.
  • Management is usually behavioral plus medication-based within sleep medicine.
  • ECT, TMS, and ketamine are not standard narcolepsy treatments.
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5. Top management articles

  1. Management review for Narcolepsy PubMed search
  2. Narcolepsy treatment guideline PubMed search
  3. Narcolepsy pharmacotherapy or psychotherapy review PubMed search