Sleep-Wake Disorders
Narcolepsy
ICD-10-CM: G47.419
1. Criteria
DSM Criteria
Criterion A
- There are recurrent periods of irrepressible need to sleep, lapsing into sleep, or napping within the same day.
- These episodes occur at least 3 times per week over the past 3 months.
DSM Criteria
Criterion B
- At least one of the following is present: episodes of cataplexy, hypocretin deficiency, or REM sleep latency abnormalities on sleep testing consistent with narcolepsy.
2. Context
- Narcolepsy is a central disorder of sleep-wake regulation marked by chronic daytime sleepiness and, in some patients, cataplexy, REM-related hallucinations, sleep paralysis, or fragmented nighttime sleep. In practice, the story often comes out as irresistible sleep episodes and a lifetime of feeling abnormally sleepy.
- Core symptom: Excessive daytime sleepiness is the anchor symptom. The person is often sleepy even after what sounds like adequate nighttime sleep.
- Cataplexy matters: When present, cataplexy strongly shifts the differential and points toward narcolepsy type 1.
- Workup: Diagnosis usually depends on sleep medicine testing, especially polysomnography plus MSLT, and sometimes CSF hypocretin data.
- Clinical focus: Common office-based measure of subjective daytime sleepiness.
3. Validated scales
Epworth Sleepiness Scale
Common office-based measure of subjective daytime sleepiness.
Multiple Sleep Latency Test
Core specialist diagnostic test in narcolepsy evaluation.
Maintenance of Wakefulness Test
Useful in follow-up when ability to stay awake is the key clinical question.
4. FDA approved treatments
FDA-approved medications for excessive daytime sleepiness in narcolepsy
Several wake-promoting agents and alerting medications carry narcolepsy labeling, though product-specific indications and age ranges differ.
FDA-approved medications for cataplexy or mixed narcolepsy symptoms
Oxybate products are important FDA-approved options when cataplexy or severe daytime sleepiness is part of the narcolepsy picture.
Common off-label medications
Interventional psychiatry modalities
- Interventional psychiatry modalities are not standard treatments for narcolepsy.
- Management is usually behavioral plus medication-based within sleep medicine.
- ECT, TMS, and ketamine are not standard narcolepsy treatments.
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5. Top management articles
- Management review for Narcolepsy PubMed search
- Narcolepsy treatment guideline PubMed search
- Narcolepsy pharmacotherapy or psychotherapy review PubMed search