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Treatments and Medications

Restless Legs Syndrome Treatments and Medications

This page summarizes the main treatment lanes attached to Restless Legs Syndrome and links back to the full diagnosis profile.

Main diagnosis page

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FDA-approved medications for restless legs syndrome

  • Several medications have FDA labeling for moderate to severe primary restless legs syndrome, with selection shaped by augmentation risk, sedation, and comorbidity.
  • Medications: Gabapentin enacarbil, Pramipexole, Ropinirole, Rotigotine

Common off-label medications

  • Pregabalin
  • Gabapentin
  • Iron replacement when indicated

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